期刊
IMMUNOBIOLOGY
卷 219, 期 9, 页码 671-679出版社
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.imbio.2014.03.018
关键词
Complement receptors; NK cells; Subsets of NK cells; Receptor expression
类别
资金
- National Natural Science Foundation of China [NSFC 81000922]
- New Century Excellent Talent Program of the Ministry of Education [NCET-11-0424]
- Medical Research Council of the UK [G1001141]
- Medical Research Council [MR/J006742/1, G1001141] Funding Source: researchfish
Integration of cellular and humoral arms of the innate immune response is fundamental to the development of powerful effector functions in host defence as well as aberrant immune responses. Here, we provide evidence in support of the relationship between complement activation and NI( cell functional modulation. We demonstrate that human NI( cells and both CD56(bright)CD16(-) and CD56(dim)CD16(+) populations express receptors known to detect the biologically active peptides C3a and C5a (i.e. C3aR, C5aR, C5L2) and the covalently-bound fragments C3b and metabolites iC3b and C3d which serve in immune adhesion (e.g. CR3, CR4). We also show that several pathogen- or tumour/inflammation-related stimuli differentially regulated those complement receptor expression. Furthermore, our results suggest that C3 fragments (C3a, iC3b) have a negative regulatory effect on IFN-gamma production in NK cells. This work provides extensive information of human complement receptors relevant to the integrated actions of complement and NK cells which has been suggested by animal studies. The observations may act as a resource that allows further understanding and exploitation of role of complement in human health and immune mediated diseases. (C) 2014 Elsevier GmbH. All rights reserved.
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