期刊
IMMUNOBIOLOGY
卷 215, 期 8, 页码 606-610出版社
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.imbio.2009.12.006
关键词
Cannabinoids receptor CB1; Cannabinoid receptor CB2; Endocannabinoid system; Immune system; Nervous system; Pro-inflammatory cytokines; Regulation
类别
Cytokines play important roles in neuroinflammation and neurodegeneration. The endocannabinoid system (ES) is comprised of the CB1 and CB2 cannabinoid receptors, endogenous ligands, and proteins involved in endocannabinoid synthesis and inactivation. The ES participates in the regulation of immune responses in the nervous system. Activation of the cannabinoid system is associated with therapeutic effects that may be mediated by the down-regulation of cytokine expression. Here we review the findings from studies on the reciprocal regulation of the immune and cannabinoid systems, which is based on functional as well as anatomical connections. We then discuss mechanisms involved in the reciprocal regulation of cytokines and the ES. (C) 2010 Elsevier GmbH. All rights reserved.
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