期刊
IMMUNOBIOLOGY
卷 214, 期 9-10, 页码 778-790出版社
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.imbio.2009.06.009
关键词
Wiskott-Aldrich Syndrome; WASp; Dendritic cells; Migration; T lymphocytes; Immunological synapse; Cell activation
类别
资金
- Wellcome Trust [057965/Z/99/B] Funding Source: Medline
- Great Ormond Street Hospital Childrens Charity [V1223] Funding Source: researchfish
Regulation of the actin cytoskeleton is crucial for many aspects of correct and cooperative functioning of immune Cells, Such as migration, antigen uptake and cell activation. The Wiskott-Aldrich Syndrome protein (WASp) is an important regulator of actin cytoskeletal rearrangements and lack of this protein results in impaired immune function. This review discusses recent new insights of the role of WASp at molecular and cellular level and evaluates how WASp deficiency affects important immunological features and how defective immune cell function contributes to compromised host defence. (C) 2009 Elsevier GmbH. All rights reserved.
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