期刊
IMMUNITY
卷 39, 期 3, 页码 432-441出版社
CELL PRESS
DOI: 10.1016/j.immuni.2013.08.037
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类别
资金
- National Institutes of Health [R37-AI029564, U54-AI057157, U19AI077437, U19AI067798, CA156330]
- NIH [AI097518, AI057141, K01DK098307]
- American Heart Association
- Cancer Research Institute
A major function of a subfamily of NLR (nucleotide-binding domain, leucine-rich repeat containing, or NOD-like receptor) proteins is in inflammasome activation, which has been implicated in a multitude of disease models and human diseases. This work will highlight key progress in understanding the mechanisms that activate the best-studied NLRs (NLRP3, NLRC4, NAIP, and NLRP1) and in uncovering inflammasome NLRs.
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