期刊
IMMUNITY
卷 38, 期 6, 页码 1164-1175出版社
CELL PRESS
DOI: 10.1016/j.immuni.2013.02.023
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类别
资金
- National Institutes of Health [RO1 AI039246-16, R37 AI054636, PO1 AI078897-04]
- New England Regional Center of Excellence in Biodefense and Emerging Infectious Diseases [GM-075252, U54 AI057159]
- Glaxo-Smith Kline [GSK-P-11-02]
- Marie Curie International Outgoing Fellowship for Career Development [220044]
Stromal-derived follicular dendritic cells (FDCs) are a major reservoir for antigen that are essential for formation of germinal centers, the site where memory and effector B cells differentiate. A long-standing question is how FDCs retain antigen in its native form for extended periods and how they display it to specific B cells. Here we found that FDCs acquired complement-coated immune complexes (ICs) from noncognate B cells via complement receptors 1 and 2 (CD35 and CD21, respectively) and rapidly internalized them by an actin-dependent pathway. ICs were retained intact within a nondegradative cycling compartment and were displayed periodically on the cell surface where they were accessible to antigen-specific B cells. This would explain how antigens are protected from damage and retained over long periods of time, while remaining accessible for B cells.
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