期刊
IMMUNITY
卷 37, 期 4, 页码 634-648出版社
CELL PRESS
DOI: 10.1016/j.immuni.2012.06.020
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资金
- Deutsche Forschungsgemeinschaft (SGBM) [SFB620/A14, GRK1104]
- Bundesministerium fur Bildung und Forschung Centrum fur Chronische Immundefizienz
- EU [PAS_241506]
- Boehringer Ingelheim
- Medical Research Council [G0800784, G0900424, G0800784B] Funding Source: researchfish
- MRC [G0800784, G0900424] Funding Source: UKRI
Innate lymphoid cells (ILCs) reside at mucosal surfaces and control immunity to intestinal infections. Type 2 innate lymphoid cells (ILC2s) produce cytokines such as IL-5 and IL-13, are required for immune defense against helminth infections, and are involved in the pathogenesis of airway hyperre-activity. Here, we have investigated the role of the transcription factor GATA-3 for ILC2 differentiation and maintenance. We showed that ILC2s and their lineage-specified bone marrow precursors (ILC2Ps), as identified here, were characterized by continuous high expression of GATA-3. Analysis of mice with temporary deletion of GATA-3 in all ILCs showed that GATA-3 was required for the differentiation and maintenance of ILC2s but not for ROR gamma t(+) ILCs. Thus, our data demonstrate that GATA-3 is essential for ILC2 fate decisions and reveal similarities between the transcriptional programs controlling ILC and T helper cell fates.
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