期刊
IMMUNITY
卷 37, 期 3, 页码 389-398出版社
CELL PRESS
DOI: 10.1016/j.immuni.2012.08.011
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-
类别
资金
- National Institutes of Health (NIH) [AI081884, AI054359, AI062428, AI064705]
- NIH/NIAID [U54AI057160]
In contrast to the extraordinary body of knowledge gained over the past three decades on the virology, pathogenesis, and immunology of HIV-1 infection, innate sensors that detect HIV-1 had remained elusive until recently. By virtue of integration, retroviridae makes up a substantial portion of our genome. Thus, immune strategies that deal with endogenous retroviruses are, by necessity, those of self-preservation and not of virus elimination. Some of the principles of such strategies may also apply for defense against exogenous retroviruses including HIV-1. Here, I highlight several sensors that have recently been revealed to be capable of recognizing distinct features of HIV-1 infection, while taking into account the host-retrovirus relationship that converges on avoiding pathogenic inflammatory consequences.
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