期刊
IMMUNITY
卷 34, 期 5, 页码 781-793出版社
CELL PRESS
DOI: 10.1016/j.immuni.2011.03.020
关键词
-
类别
资金
- National Institutes of Health [AI42767, AI46653, AI50073, AI59752]
- Leukemia and Lymphoma Society
Infection or vaccination confers heightened resistance to pathogen rechallenge because of quantitative and qualitative differences between naive and primary memory T cells. Herein, we show that secondary (boosted) memory CD8(+) T cells were better than primary memory CD8(+) T cells in controlling some, but not all acute infections with diverse pathogens. However, secondary memory CD8(+) T cells were less efficient than an equal number of primary memory cells at preventing chronic LCMV infection and are more susceptible to functional exhaustion. Importantly, localization of memory CD8(+) T cells within lymph nodes, which is reduced by antigen restimulation, was critical for both viral control in lymph nodes and for the sustained CD8(+) T cell response required to prevent chronic LCMV infection. Thus, repeated antigen stimulation shapes memory CD8(+) T cell populations to either enhance or decrease per cell protective immunity in a pathogen-specific manner, a concept of importance in vaccine design against specific diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据