期刊
IMMUNITY
卷 35, 期 2, 页码 260-272出版社
CELL PRESS
DOI: 10.1016/j.immuni.2011.06.005
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类别
资金
- National Institutes of Health (NIH) [R01-AR056632, U19 AI057234]
- Dermatology Foundation
- American Skin Association
- Baylor Health Care System Foundation
- Burroughs Wellcome Fund Career Award for Medical Scientists
Skin-resident dendritic cells (DCs) are well positioned to encounter cutaneous pathogens and are required for the initiation of adaptive immune responses. There are at least three subsets of skin DC-Langerhans cells (LC), Langerin(+) dermal DCs (dDCs), and classic dDCs. Whether these subsets have distinct or redundant function in vivo is poorly understood. Using a Candida albicans skin infection model, we have shown that direct presentation of antigen by LC is necessary and sufficient for the generation of antigen-specific T helper-17 (Th17) cells but not for the generation of cytotoxic lymphocytes (CTLs). In contrast, Langerin(+) dDCs are required for the generation of antigen specific CTL and Th1 cells. Langerin(+) dDCs also inhibited the ability of LCs and classic DCs to promote Th17 cell responses. This work demonstrates that skin-resident DC subsets promote distinct and opposing antigen-specific responses.
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