期刊
IMMUNITY
卷 31, 期 2, 页码 331-341出版社
CELL PRESS
DOI: 10.1016/j.immuni.2009.08.001
关键词
-
类别
资金
- Science Foundation Ireland
Th17 cells, CD4(+) T cells that secrete interleukin-17 (IL-17), are pathogenic in autoimmune diseases and their development and expansion is driven by the cytokines IL-6, TGF-beta, IL-21, IL-1, and IL-23. However, there are also innate sources of IL-17. Here, we show that gamma delta T cells express IL-23R and the transcription factor ROR gamma t and produce IL-17, IL-21, and IL-22 in response to IL-1 beta and IL-23, without T cell receptor engagement. IL-17-producing gamma delta T cells were found at high frequency in the brain of mice with experimental autoimmune encephalomyelitis (EAE). gamma delta T cells activated by IL-1 beta and IL-23 promoted IL-17 production by CD4(+) T cells and increased susceptibility to EAE, suggesting that gamma delta T cells act in an amplification loop for IL-1 7 production by Th17 cells. Our findings demonstrate that gamma delta T cells activated by IL-1 beta and IL-23 are an important source of innate IL-17 and IL-21 and provide an alternative mechanism whereby IL-1 and IL-23 may mediate autoimmune inflammation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据