期刊
IMMUNITY
卷 29, 期 3, 页码 325-342出版社
CELL PRESS
DOI: 10.1016/j.immuni.2008.08.006
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资金
- National Institutes of Health [R01 A1069259, R01 A1072252, P01 A1078897, P01 HL56949]
- Canadian Institutes of Health Research
- Austrian Academy of Sciences
Dendritic cells (DCs) are critical for adaptive immunity and tolerance. Most DCs are strategically positioned as immune sentinels poised to respond to invading pathogens in tissues throughout the body. Differentiated DCs and their precursors also circulate in blood and can get rapidly recruited to sites of challenge. Within peripheral tissues, DCs collect antigenic material and then traffic to secondary lymphoid organs, where they communicate with lymphocytes to orchestrate adaptive immune responses. Hence, the migration and accurate positioning of DCs is indispensable for immune surveillance. Here, we review the molecular traffic signals that govern the migration of DCs throughout their life cycle.
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