4.8 Editorial Material

Genetic background and the dilemma of translating mouse studies to humans

期刊

IMMUNITY
卷 28, 期 1, 页码 1-4

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CELL PRESS
DOI: 10.1016/j.immuni.2007.12.008

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资金

  1. NATIONAL CANCER INSTITUTE [ZIABC010391, Z01BC010391, Z01BC010390, ZICBC011198, ZIABC010390] Funding Source: NIH RePORTER
  2. NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [ZIAAR041101, Z01AR041101, Z01AR041155, ZIAAR041155] Funding Source: NIH RePORTER

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C57BL/6 genetically modified mouse models are the accepted gold standard in biological studies. However, an increasing failure of translating the findings to human (patho)physiology casts doubt on using a single strain to address many questions.

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