期刊
ILAR JOURNAL
卷 55, 期 2, 页码 221-232出版社
OXFORD UNIV PRESS
DOI: 10.1093/ilar/ilu002
关键词
animal models; depression; social defeat; stress
Depression is one of the most disabling medical conditions in the world today, yet its etiologies remain unclear and current treatments are not wholly effective. Animal models are a powerful tool to investigate possible causes and treatments for human diseases. We describe an animal model of social defeat as a possible model for human depression. We discuss the paradigm, behavioral correlates to depression, and potential underlying neurobiological mechanisms with an eye toward possible future therapies.
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