期刊
ILAR JOURNAL
卷 49, 期 1, 页码 35-53出版社
OXFORD UNIV PRESS
DOI: 10.1093/ilar.49.1.35
关键词
disease model; magnetic resonance imaging; microscopy; mouse; rat; rodent
资金
- NATIONAL CANCER INSTITUTE [U24CA092656] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [P41RR005959, U24RR021760] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL055348] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [T32EB001040] Funding Source: NIH RePORTER
- NCI NIH HHS [CA092656, U24 CA092656-08, U24 CA092656] Funding Source: Medline
- NCRR NIH HHS [P41 RR05959/U24, U24 RR021760-05, P41 RR005959-18, U24 RR021760, P41 RR005959] Funding Source: Medline
- NHLBI NIH HHS [R01 HL055348-07, R01 HL055348] Funding Source: Medline
- NIBIB NIH HHS [T32 EB001040-05, 1T32 EB001040, T32 EB001040] Funding Source: Medline
Small animal magnetic resonance microscopy (MRM) has evolved significantly from testing the boundaries of imaging physics to its expanding use today as a tool in noninvasive biomedical investigations. MRM now increasingly provides functional information about living animals, with images of the beating heart, breathing lung, and functioning brain. Unlike clinical MRI, where the focus is on diagnosis, MRM is used to reveal fundamental biology or to noninvasively measure subtle changes in the structure or function of organs during disease progression or in response to experimental therapies. High-resolution anatomical imaging reveals increasingly exquisite detail in healthy animals and subtle architectural aberrations that occur in genetically altered models. Resolution of 100 mu m in all dimensions is now routinely attained in living animals, and (10 mu m)(3) is feasible in fixed specimens. Such images almost rival conventional histology while allowing the object to be viewed interactively in any plane. In this review we describe the state of the art in MRM for scientists who may be unfamiliar with this modality but who want to apply its capabilities to their research. We include a brief review of MR concepts and methods of animal handling and support, before covering a range of MRM applications-including the heart, lung, and brain-and the emerging field of MR histology. The ability of MRM to provide a detailed functional and anatomical picture in rats and mice, and to track this picture over time, makes it a promising platform with broad applications in biomedical research.
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