期刊
IET SYSTEMS BIOLOGY
卷 3, 期 3, 页码 203-U110出版社
INST ENGINEERING TECHNOLOGY-IET
DOI: 10.1049/iet-syb.2008.0089
关键词
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资金
- National Research Initiative of the USDA Cooperative State Research, Education and Extension Service [2006-35504-17359]
- National Cancer Institute [5U54CA132383]
- New Mexico State University
- National Science Foundation CREST [HRD-0420407]
Composed of linear difference equations, a discrete dynamical system (DDS) model was designed to reconstruct transcriptional regulations in gene regulatory networks (GRNs) for ethanologenic yeast Saccharomyces cerevisiae in response to 5-hydroxymethylfurfural (HMF), a bioethanol conversion inhibitor. The modelling aims at identification of a system of linear difference equations to represent temporal interactions among significantly expressed genes. Power stability is imposed on a system model under the normal condition in the absence of the inhibitor. Non-uniform sampling, typical in a time-course experimental design, is addressed by a log-time domain interpolation. A statistically significant DDS model of the yeast GRN derived from time-course gene expression measurements by exposure to HMF, revealed several verified transcriptional regulation events. These events implicate Yap1 and Pdr3, transcription factors consistently known for their regulatory roles by other studies or postulated by independent sequence motif analysis, suggesting their involvement in yeast tolerance and detoxification of the inhibitor.
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