期刊
IET NANOBIOTECHNOLOGY
卷 12, 期 8, 页码 1067-1073出版社
WILEY
DOI: 10.1049/iet-nbt.2018.5076
关键词
ultraviolet spectra; nanomedicine; nanostructured materials; visible spectra; X-ray diffraction; antibacterial activity; nanoparticles; zinc compounds; scanning electron microscopy; microorganisms; nanofabrication; drugs; transmission electron microscopy; X-ray chemical analysis; health and safety; particle size; renewable materials; diseases; Fourier transform infrared spectra; flavonoid content; natural reducing stabilisation facilitators; ZnO nanoparticles synthesis; antileishmanial efficacy; Verbena tennuisecta; Verbena officinales; phytochemical analysis; phenolic content; ultraviolet-visible spectroscopy; Fourier transform infrared spectroscopy; scanning electron microscopy; X-ray diffraction; transmission electron microscopy; energy dispersive X-ray analysis; particle size; leishmaniasis treatment; leaf extracts; medication scheme; stabilisation facilitator; capping facilitator; size 14; 0 nm to 31; 0 nm; size 65; 0 nm to 75; 0 nm; ZnO
This study describes ZnO NPs biosynthesis using leaf extracts of Verbena officinalis and Verbena tenuisecta. The extracts serve as natural reducing, capping and stabilization facilitators. Plant extracts phytochemical analysis, revealed that V. officinalis showed higher total phenolic and flavonoid content (22.12 and 6.38 mg g (-1) DW) as compared to V. tennuisecta (12.18 and 2.7 mg g (-1) DW). ZnO NPs were characterised by ultraviolet-visible spectroscopy, Fourier transform infrared, X-ray diffraction, scanning electron microscope, transmission electron microscopy (TEM) and energy dispersive X-ray. TEM analysis of ZnO NPs reveals rod and flower shapes and were in the range of 65-75 and 14-31nm, for V. tenuisecta and V. officinalis, respectively. Bio-potential of ZnO NPs was examined through their leishmanicidal potential against Leishmania tropica. ZnO NPs showed potent leishmanicidal activity with 250 mu g ml(-1) being the most potent concentration. V. officinalis mediated ZnO NPs showed more potent leishmanicidal activity compared to V. tenuisecta mediated ZnO NPs due to their smaller size and increased phenolics doped onto its surface. These results can be a step forward towards the development of novel compounds that can efficiently replace the current medication schemes for leishmaniasis treatment.
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