期刊
IEEE-ASME TRANSACTIONS ON MECHATRONICS
卷 19, 期 4, 页码 1289-1299出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TMECH.2013.2279775
关键词
Motor; MRI-compatible; MRI-Safe; pneumatic; prostate biopsy; robot
类别
资金
- Prostate Cancer Research Program (PCRP) of the Department of Defense (DOD) [W81XWH0810221]
- U.S. Department of Defense (DOD) [W81XWH0810221] Funding Source: U.S. Department of Defense (DOD)
This paper reports the development of an MRI-Safe robot for direct (interventional) MRI-guided endorectal prostate biopsy. The robot is constructed of nonmagnetic and electrically nonconductive materials, and is electricity free, using pneumatic actuation and optical sensors. Targeting biopsy lesions of MRI abnormality presents substantial clinical potential for the management of prostate cancer. This paper describes MRI-Safe requirements and presents the kinematic architecture, design, and construction of the robot, and a comprehensive set of preclinical tests for MRI compatibility and needle targeting accuracy. The robot has a compact and simple three degree-of-freedom (DoF) structure, two for orienting a needle-guide and one to preset the depth of needle insertion. The actual insertion is performed manually through the guide and up to the preset depth. To reduce the complexity and size of the robot next to the patient, the depth setting DoF is remote. Experimental results show that the robot is safe to use in any MRI environment (MRI-Safe). Comprehensive MRI tests show that the presence and motion of the robot in the MRI scanner cause virtually no image deterioration or signal-to-noise ratio change. Robot's accuracy in bench test, CT-guided in-vitro, MRI-guided in-vitro, and animal tests are 0.37, 1.10, 2.09, and 2.58 mm, respectively. These values are acceptable for clinical use.
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