期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 56, 期 -, 页码 467-472出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2015.07.022
关键词
Zinc; Stent; Bioabsorbable; Biocompatible; Corrosion; Hyperplasia
资金
- Michigan Initiative for Innovation and Entrepreneurship (Technology Commercialization Fund) [3093231]
- U.S. National Institute of Health (National Institute of Biomedical Imaging and Bioengineering) [1R21EB019118-01A1]
- American Heart Association (Midwest Affiliate) predoctoral fellowship
- Michigan Space Grant Consortium undergraduate research fellowship
Although corrosion resistant bare metal stents are considered generally effective, their permanent presence in a diseased artery is an increasingly recognized limitation due to the potential for long-term complications. We previously reported that metallic zinc exhibited an ideal biocorrosion rate within murine aortas, thus raising the possibility of zinc as a candidate base material for endovascular stenting applications. This study was undertaken to further assess the arterial biocompatibility of metallic zinc. Metallic zinc wires were punctured and advanced into the rat abdominal aorta lumen for up to 6.5 months. This study demonstrated that metallic zinc did not provoke responses that often contribute to restenosis. Low cell densities and neointimal tissue thickness, along with tissue regeneration within the corroding implant, point to optimal biocompatibility of corroding zinc. Furthermore, the lack of progression in neointimal tissue thickness over 6.5 months or the presence of smooth muscle cells near the zinc implant suggest that the products of zinc corrosion may suppress the activities of inflammatory and smooth muscle cells. (C) 2015 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据