期刊
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 53, 期 -, 页码 262-271出版社
ELSEVIER
DOI: 10.1016/j.msec.2015.04.037
关键词
Bioactive glass; Electrospinning; Fibers; Tissue engineering applications
资金
- Scientific and Technical Research Council of Turkey (TUBITAK), 1001 grant program for Scientific And Technological Research Projects [111M766]
In this study, silicate based 13-93 bioactive glass fibers were prepared through sol-gel processing and electrospinning technique. A precursor solution containing poly (vinyl alcohol) and bioactive glass sol was used to produce fibers. The mixture was electrospun at a voltage of 20 kV by maintaining tip to a collector distance of 10 cm. The amorphous glass fibers with an average diameter of 464 +/- 95 nm were successfully obtained after calcination at 625 degrees C. Hydroxyapatite formation on calcined 13-93 fibers was investigated in simulated body fluid (SBF) using two different fiber concentrations (0.5 and 1 mg/ml) at 37 degrees C. When immesed in SBF, conversion to a calcium phosphate material showed a strong dependence on the fiber concentration. At 1 mg/ml, the surface of the fibers converted to the hydroxyapatite-like material in SBF only after 30 days. At lower solid concentrations (0.5 mg/ml), an amorphous calcium phosphate layer formation was observed followed by the conversion to hydroxyapatite phase after 7 days of immersion. The XIT (2,3-Bis-(2-Methoxy-4-Nitro-5-Sulfopheny1)-2H-Tetrazolium-5-Carboxanilide) assay was conducted to evaluate the osteoblast cell response to the bioactive glass fibers. (C) 2015 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据