A zeolite modified carbon paste electrode as useful sensor for voltammetric determination of acetaminophen

The voltamrnetric behavior of a carbon paste electrode modified with Co(II)-exchanged zeolite A (Co(II)-A/ZMCPE) for determination of acetaminophen was studied. The proposed electrode showed a diffusion controlled reaction with the electron transfer rate constant (K-s) of 0.44 s(-1) and charge transfer coefficient of 0.73 in the absence of acetaminophen. A linear voltammetric response was obtained in the range of 0.1 to 190 mu mol L-1 of acetaminophen [r(2) = 0.9979, r = 0.9989 (n = 10)] with a detection limit of 0.04 mu mol L-1. The method was successfully applied to the analysis of acetaminophen in some drugs. (C) 2015 Elsevier B.V. All rights reserved.