期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 48, 期 -, 页码 372-377出版社
ELSEVIER
DOI: 10.1016/j.msec.2014.12.021
关键词
Nanofibers; Drug delivery system; (Copaifera sp.) oil; Solution blow spinning; Antimicrobial activity
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, CNPQ [476362/2012-1, 562.703/2010-4]
- Laboratorio de Solidificacao Rapida (LSR) da UFPB
In this study poly(lactic add) (PLA) and polyvinylpyrrolidone (PVP) micro- and nanofiber mats loaded with Copaiba (Copaifera sp.) oil were produced by solution blow spinning (SBS). The Copaiba (Copaifera sp.) oil was characterized by gas chromatography (GC). Neat PLA and four PLA/PVP blends containing 20% (wt.%) oil were spun and characterized by scanning electron microscopy (SEM) and by studying the surface contact angle, in vitro release rate, and antimicrobial activity. All compositions evaluated were able to produce continuous and smooth fibers by SBS. The addition of PVP increased fiber diameter, and decreased the surface contact angle. GC analysis demonstrated that the main component of the Copaiba oil was beta-caryophyllene, a known antimicrobial agent. In vitro release tests of Copaiba oil volatiles demonstrated a higher release rate in fibers containing PVP. Fiber mats made from blends containing higher amounts of PVP had greater antimicrobial action against Staphylococcus aureus. The results confirm the potential of the fiber mats for use in controlled drug release and could lead to promising applications in the biomedical field. (C) 2014 Elsevier B.V. All rights reserved.
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