期刊
IEEE TRANSACTIONS ON PLASMA SCIENCE
卷 47, 期 2, 页码 1093-1099出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TPS.2018.2867431
关键词
Apoptosis; atmospheric oxygen plasma irradiation; mitogen-activated protein kinase (MAPK) sequence; oral cancer cell; p53 protein; phosphorylation
资金
- JSPS KAKENHI [JP17H02806]
Oral cancer cell HSC3 is inactivated by the direct irradiation of oxygen plasma generated by torch-type oxygen dielectric barrier discharge. Selective inactivation of the cancer cells is observed at the discharge voltage of 4.2 kV, where normal cells suffer no damages from the plasma. Inactivation mechanism of HSC3 cells irradiated by the plasma is considered as the apoptosis. Activation of mitogen-activated protein kinase and p53 proteins owing to the phosphorylation is one of the pathways to the cancer cell apoptosis.
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