期刊
MATERIALS LETTERS
卷 150, 期 -, 页码 52-54出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matlet.2015.02.120
关键词
Coaxial electrospinning; Shell/core structure; Membranes; Sustained release
资金
- Shanghai Major Construction Projects [11XK18BXKCZ1205]
- Program of Shanghai Science and Technology Capacity Building Project Local Universities [11490501500]
- Shanghai Graduate Innovation Entrepreneurial Training Projects
Model drug-loaded coaxial electrospun PVP@nano-biopolymers core-shell composite nanofibers were fabricated by a facile coaxial electrospinning successfully. The model drug FA, which is a kind of lipid microsphere non-steroidal anti-inflammatory drug, was shown to be successfully adsorbed in the PVP, and the formed FA/PVP/biopolymers composite nanofibers exhibit a uniform and smooth morphology. The loaded FA within the PVP/biopolymers coaxial nanofibers showed a sustained release profile. With the significantly reduced burst-release profile, the developed FA/PVP/biopolymers composite nanofibers were proposed to be a promising material in the fields of pharmaceutical science. (C) 2015 Elsevier B.V. All rights reserved.
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