期刊
MATERIALS LETTERS
卷 145, 期 -, 页码 174-176出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matlet.2015.01.092
关键词
Biomaterials; Polymer; Shape memory materials; Zwitterionic; Biocompatibility; Antibacterial
资金
- National Natural Science Foundation of China [21104045]
- Special Research Foundation of Shenzhen Oversea High-level Talents [KQCX20120807153115869]
- Science and Technology Project of Shenzhen City [JCYJ20140828163633993]
- Nanshan District Key Lab for Biopolymers and Safety Evaluation [KC2014ZDZJ0001A]
Zwitterionic polyurethanes show great potential applications in biomedical field. This paper reports a novel approach to prepare zwitterionic polyurethanes from N-methyldiethanolamine (MDEA), hexamethylene diisocyanate (HDI) and 1,3-propanesultone (1,3-PS). Results show that sulfobetaine groups are successfully grafted onto the MDEA based polyurethanes. The introduction of sulfobetaine group improves cell biocompatibility of polyurethanes. Moreover, good antibacterial activity of zwitterions is retained in this MDEA based polyurethanes. This work provides another substantiation to integrate antimicrobial and non-fouling properties. (C) 2015 Elsevier B.V. All rights reserved.
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