期刊
IEEE TRANSACTIONS ON NANOBIOSCIENCE
卷 7, 期 4, 页码 267-275出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TNB.2008.2011857
关键词
Bio-heat equation; finite difference algorithm; heat transfer; low Curie temperature nanoparticle; magnetic fluid hyperthermia; Neel relaxation
资金
- University of Alabama
This study develops and solves two-dimensional convective-conductive coupled partial differential equations based on Pennes' bio-heat transfer model using low Curie temperature nanoparticles (LCTNPs) to illustrate thermal behavior quantitatively within tumor-normal composite tissue by establishing a multi-region finite difference algorithm. The model combines Neel relaxation and temperature-variant saturation magnetization derived from Brillouin Equation and Curie-Weiss Law. The numerical results indicate that different deposition patterns of LCTNP and boundary conditions directly effect the steady state temperature distribution. Compared with high Curie temperature nanoparticles (HCTNPs), optimized distributions of LCTNPs within tumorous tissue scan be used to control the temperature increase in tumors for hyperthermia treatment using an external magnetic field while healthy tissue surrounding it tumor can be kept closer to normal body tissue, reducing the side effects observed in whole body and regional hyperthermia therapy.
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