期刊
YEAR IN DIABETES AND OBESITY
卷 1353, 期 -, 页码 60-71出版社
BLACKWELL SCIENCE PUBL
DOI: 10.1111/nyas.12807
关键词
type 1 diabetes mellitus; type 2 diabetes mellitus; cognitive dysfunction; brain; memory
资金
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [KL2TR000113] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK099137] Funding Source: NIH RePORTER
- NCATS NIH HHS [KL2 TR000113, 5KL2TR000113] Funding Source: Medline
- NIDDK NIH HHS [R01 DK099137] Funding Source: Medline
Both type 1 and type 2 diabetes have been associated with reduced performance on multiple domains of cognitive function and with structural abnormalities in the brain. With an aging population and a growing epidemic of diabetes, central nervous system-related complications of diabetes are expected to rise and could have challenging future public health implications. In this review, we will discuss the brain structural and functional changes that have been associated with type 1 and type 2 diabetes. Diabetes duration and glycemic control may play important roles in the development of cognitive impairment in diabetes, but the exact underlying pathophysiological mechanisms causing these changes in cognition and structure are not well understood. Future research is needed to better understand the natural history and the underlying mechanisms, as well as to identify risk factors that predict who is at greatest risk of developing cognitive impairment. This information will lead to the development of new strategies to minimize the impact of diabetes on cognitive function.
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