期刊
ADDICTION REVIEWS 2015
卷 1349, 期 -, 页码 1-45出版社
BLACKWELL SCIENCE PUBL
DOI: 10.1111/nyas.12762
关键词
accumbens; caudate nucleus; putamen; cocaine; Parkinson's disease; drug addiction
资金
- NCRR NIH HHS [P51 RR000165] Funding Source: Medline
- NIH HHS [P51 OD011132] Funding Source: Medline
- NINDS NIH HHS [P50 NS071669, R01 NS062876, R01 NS083386, R01 NS037948] Funding Source: Medline
Striatal cholinergic interneurons (ChIs) are central for the processing and reinforcement of reward-related behaviors that are negatively affected in states of altered dopamine transmission, such as in Parkinson's disease or drug addiction. Nevertheless, the development of therapeutic interventions directed at ChIs has been hampered by our limited knowledge of the diverse anatomical and functional characteristics of these neurons in the dorsal and ventral striatum, combined with the lack of pharmacological tools to modulate specific cholinergic receptor subtypes. This review highlights some of the key morphological, synaptic, and functional differences between ChIs of different striatal regions and across species. It also provides an overview of our current knowledge of the cellular localization and function of cholinergic receptor subtypes. The future use of high-resolution anatomical and functional tools to study the synaptic microcircuitry of brain networks, along with the development of specific cholinergic receptor drugs, should help further elucidate the role of striatal ChIs and permit efficient targeting of cholinergic systems in various brain disorders, including Parkinson's disease and addiction.
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