期刊
SPECIAL ISSUE: RESPIRATORY SCIENCE
卷 1365, 期 -, 页码 5-14出版社
BLACKWELL SCIENCE PUBL
DOI: 10.1111/nyas.12733
关键词
hydrogen sulfide; nitric oxide; reactive oxygen species; redox signaling; signal transduction
类别
资金
- MRC [MR/L01985X/1] Funding Source: UKRI
- Medical Research Council [MR/L01985X/1] Funding Source: researchfish
Signaling in cells involving reactive compounds is well established. Reactive oxygen species (ROS) and nitric oxide (NO) are known to be extremely influential in the control of a range of physiological responses in many organisms, from animals to plants. Often, their generation is triggered in reaction to stress, and it is common for ROS and NO metabolism to interact to give a coordinated response. Recently, hydrogen sulfide (H2S) has also been found to be an important signaling molecule, being shown to be involved in vascular tone in animals. Of relevance to respiration, in plants, H2S has been shown to affect stomatal apertures and the transpiration stream, while, in animals, H2S has been shown to be a source of electrons for ATP synthesis in mitochondria. However, in signaling, H2S does notwork in isolation, and it is likely that it will interact with both ROS and NO. This may occur at a variety of levels, from influencing the generation of such molecules, interacting directly, or competing for control of downstream signaling events. A full understanding of the impact of this toxic molecule in the control of cells requires all these factors to be taken into account.
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