期刊
TARGETING THE LYSOSOME
卷 1371, 期 -, 页码 45-54出版社
BLACKWELL SCIENCE PUBL
DOI: 10.1111/nyas.12953
关键词
lysosome; cell death; autophagy; apoptosis; cancer therapy; drug resistance
资金
- NCI NIH HHS [P01 CA114046, R01 CA169134, R01 CA198015] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA198015, P01CA114046, R01CA169134, P30CA016520] Funding Source: NIH RePORTER
Lysosomes are membrane-bound intracellular organelles that receive macromolecules delivered by endocytosis, phagocytosis, and autophagy for degradation and recycling. Over the last decade, advances in lysosome research have established a broad role for the lysosome in the pathophysiology of disease. In this review, we highlight the recent discoveries in lysosome biology, with an emphasis on their implications for cancer therapy. We focus on targeting the lysosome in cancer by exploring lysosomal biogenesis and its role in the crosstalk between apoptosis and autophagy. We also discuss how lysosomal inhibition could emerge as a new therapeutic strategy to overcome drug resistance in cancer.
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