期刊
TRANSLATIONAL NEUROSCIENCE IN PSYCHIATRY
卷 1344, 期 -, 页码 78-91出版社
BLACKWELL SCIENCE PUBL
DOI: 10.1111/nyas.12742
关键词
major depressive disorder; oscillations; oscillatory synchrony; antidepressant treatment; antidepressant medication; mechanism of action; biomarkers; biosignatures; intermediate phenotype; thalamocortical dysrhythmia; quantitative electroencephalography; neuromodulation
资金
- National Institutes of Health (NIH)
- Wyeth Pharmaceuticals
- Novartis Pharmaceuticals
- Seaside Therapeutics
- Genentech
- Shire Pharmaceuticals
- Neuronetics
- Eli Lilly and Company
- Neurosigma
- Aspect Medical Systems/Covidien
- Cyberonics
- High Q Foundation
- John E. Fetzer Foundation
- John A. Hartford Foundation
- MedAvante
- Merck
- Brain and Behavior Research Foundation
- NIH
- NeoSync
- Novartis
- Pfizer
- Sepracor/Sunovion
- West Coast College of Biological Psychiatry
Treatments formajor depressive disorder (MDD) act at different hierarchical levels of biological complexity, ranging from the individual synapse to the brain as a whole. Theories of antidepressant medication action traditionally have focusedon the level of cell-to-cell interactionand synapticneurotransmission. However, recent evidence suggests that modulation of synchronized electrical activity in neuronal networks is a common effect of antidepressant treatments, including not only medications, but also neuromodulatory treatments such as repetitive transcranial magnetic stimulation. Synchronization of oscillatory network activity in particular frequency bands has been proposed to underlie neurodevelopmental and learning processes, and also may be important in the mechanism of action of antidepressant treatments. Here, we review current research on the relationship between neuroplasticity and oscillatory synchrony, which suggests that oscillatory synchrony may help mediate neuroplastic changes related to neurodevelopment, learning, and memory, as well as medication and neuromodulatory treatment for MDD. We hypothesize that medication and neuromodulation treatments may have related effects on the rate and pattern of neuronal firing, and that these effects underlie antidepressant efficacy. Elucidating the mechanisms through which oscillatory synchrony may be related to neuroplasticity could lead to enhanced treatment strategies for MDD.
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