期刊
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
卷 61, 期 6, 页码 1658-1663出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TIM.2012.2188350
关键词
Cavitation; drug delivery; piezopolymer; therapy for wounds; ultrasound transducer
资金
- Faculty of Pharmacy, Magna Graecia University of Catanzaro (UMG), Catanzaro, Italy
Ultrasound energy at frequencies lower than 200 kHz has recently been used in the medical field to improve transdermal drug transport and to achieve a more suitable therapeutic approach. Low-frequency ultrasound energy was shown to be more effective than high-frequency ultrasound energy, so low-frequency ultrasound is attracting its share of attention in the medical field. In this paper, we take into consideration the most promising applications of low-frequency ultrasound with emphasis on transducer technology and measurements. In particular, a piezopolymer transducer is proposed, originally aimed at emulating the biosonar of bats, which has a low acoustic impedance in correspondence to biological tissue. The transducer is light, small, and inexpensive and could be used for medical applications, a possibility of which is a potential device for improving the cutaneous passage of drug compounds.
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