PVA and PEG functionalised LSMO nanoparticles for magnetic fluid hyperthermia application

La0.7Sr0.3MnO3 magnetic nanoparticles are synthesized by a solution combustion method and functionalised with polyvinyl alcohol and polyethylene glycol. The induction heating characteristics of coated magnetic nanoparticles (42 degrees C) were observed at a reasonably low concentration (5 mg/mL). Remarkably, coated magnetic nanoparticles exhibited a promisingly high specific absorption rate with varying magnetic field and constant frequency. The surface analysis is carried out by X-ray photoelectron spectroscopy. A reduction in the agglomeration of the particles was observed when the magnetic nanoparticles were functionalised with polyvinyl alcohol or polyethylene glycol and can be confirmed by transmission electron microscopy and dynamic light scattering studies. Vibrating sample magnetometer measurements indicate superparamagnetic behaviour at room temperature before and after coating. Colloidal stability revealed a considerably higher zeta potential value for coated system. In vitro cytotoxicity test of the magnetic nanoparticles indicates that coated nanoparticles have no significant effect on cell viability within the tested concentrations (1-5 mg ml(-1)) as compared to uncoated La0.7Sr0.3MnO3. All these findings explore the potentiality of La0.7Sr0.3MnO3 nanoparticles for magnetic fluid hyperthermia. (C) 2015 Elsevier Inc. All rights reserved.