期刊
B-1 CELL DEVELOPMENT AND FUNCTION
卷 1362, 期 -, 页码 143-152出版社
BLACKWELL SCIENCE PUBL
DOI: 10.1111/nyas.12790
关键词
lymphocytes; B cells; human; phenotype; antibody
资金
- Lupus Research Institute
- [R01AI029690]
- [R21AI095787]
- [R21AI099517]
B-1 cells represent a subpopulation of B cells that has been extensively studied in mice and shown to spontaneously generate natural antibody that provides antimicrobial protection and helps dispose of cellular debris. Mouse B-1 cells originate from distinct progenitors and express additional immune properties that include phagocytosis, antigen presentation, immune suppression, and polarization of T cell differentiation. Confusion regarding the existence of human B-1 cells with mouse B-1-like properties has recently been addressed by identification of a new phenotypic profile. Human B-1 cells spontaneously secrete antibody and are distinct from other circulating B cell populations by multiple criteria. A number of laboratories have recently reported on changes to the human B-1 cell population in human disease.
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