期刊
IEEE TRANSACTIONS ON DIELECTRICS AND ELECTRICAL INSULATION
卷 17, 期 6, 页码 1888-1894出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TDEI.2010.5658243
关键词
Electrorotation; transmembrane voltage; cellular electroporation; ultrashort pulse; bio-electric simulation
资金
- Office of Research and Sponsored Programs (ORSP) of Central Michigan University
Cellular electroporation involves electrically driven dielectric membrane breakdown, and has several bio-medical applications. Electrorotation and changes in its characteristic spectra could be a useful method for monitoring electroporation. Towards this goal, a simulation analyses is presented to probe electrorotation features arising from poration. Breakdown of both outer plasma membrane and inner organelle membranes are included based on a double-shell dielectric model. Our results demonstrate the feasibility of such monitoring, and show that anti-field rotation would be a good indicator of outer plasma membrane rupture, and the degree of poration.
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