期刊
MARINE DRUGS
卷 14, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/md14010008
关键词
Anabaenopeptins; nodulapeptins; Baltic Sea; cyanobacteria; Nodularia spumigena; Aphanizomenon flos-aquae; Dolichospermum spp.; carboxypeptidase A; protein phosphatase 1
资金
- Svenska Litteratursallskapet i Finland
- EU [245137, KBBE-2009-3-2-01]
- National Science Centre in Poland [NCN2013/0518/B/NZ8/01222]
Anabaenopeptins, bioactive cyclic hexapeptides, were isolated by preparative reversed-phase high performance liquid chromatography from an extract of Baltic Sea cyanobacterial bloom material composed of Nodularia spumigena (50%), Aphanizomenon flos-aquae (40%) and Dolichospermum spp. (10%). Five new anabaenopeptins and nine previously known anabaenopeptins were isolated, and their putative structures were determined by tandem mass spectrometry. The activity of the peptides against carboxypeptidase A and protein phosphatase 1 as well as chymotrypsin, trypsin and thrombin was tested. All anabaenopeptins inhibited carboxypeptidase A (apart from one anabaenopeptin variant) and protein phosphatase 1 with varying potency, but no inhibition against chymotrypsin, trypsin and thrombin was observed.
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