期刊
MARINE DRUGS
卷 13, 期 12, 页码 7138-7149出版社
MDPI AG
DOI: 10.3390/md13127060
关键词
Briareum; briarane; octocoral; anti-inflammatory; iNOS; COX-2
资金
- Asia-Pacific Ocean Research Center, National Sun Yat-sen University
- National Museum of Marine Biology and Aquarium
- National Dong Hwa University
- Ministry of Science and Technology [NSC 103-2911-I-002-303, MOST 104-2911-I-002-302, MOST 103-2325-B-039-008, MOST 103-2325-B-039-007-CC1, MOST 103-2325-B-291-001, MOST 104-2325-B-291-001, MOST 104-2320-B-291-001-MY3, NSC 101-2320-B-291-001-MY3]
- National Health Research Institutes [NHRI-EX103-10241BI]
- Chinese Medicine Research Center, China Medical University (the Ministry of Education, the Aim for the Top University Plan), Taiwan
Five new 13,14-epoxybriarane diterpenoids, briarenolides U-Y (1-5), were isolated from the octocoral Briareum sp. The structures of briaranes 1-5 were elucidated by spectroscopic methods. Briarenolides U-Y (1-5) were found to significantly inhibit the expression of the pro-inflammatory inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells.
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