期刊
MARINE DRUGS
卷 13, 期 12, 页码 7055-7066出版社
MDPI AG
DOI: 10.3390/md13127056
关键词
Mycosporine-like amino acids (MAAs); wound healing; mitogen-activated protein (MAP) kinases; extracellular signal-regulated kinases (ERK); c-Jun N-terminal kinases (JNK)
资金
- Ministry of Oceans and Fisheries [20150071]
- National Research Foundation [NRF-2013R1A1A1007693, 2014K1A3A1A19066980]
- [NRF-2015H1A2A1032009]
- National Research Foundation of Korea [2014K1A3A1A19066980] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Mycosporine-like amino acids (MAAs) are secondary metabolites found in diverse marine, freshwater, and terrestrial organisms. Evidence suggests that MAAs have several beneficial effects on skin homeostasis such as protection against UV radiation and reactive oxygen species (ROS). In addition, MAAs are also involved in the modulation of skin fibroblasts proliferation. However, the regulatory function of MAAs on wound repair in human skin is not yet clearly elucidated. To investigate the roles of MAAs on the wound healing process in human keratinocytes, three MAAs, Shinorine (SH), Mycosporine-glycine (M-Gly), and Porphyra (P334) were purified from Chlamydomonas hedlyei and Porphyra yezoensis. We found that SH, M-Gly, and P334 have significant effects on the wound healing process in human keratinocytes and these effects were mediated by activation of focal adhesion kinases (FAK), extracellular signal-regulated kinases (ERK), and c-Jun N-terminal kinases (JNK). These results suggest that MAAs accelerate wound repair by activating the FAK-MAPK signaling pathways. This study also indicates that MAAs can act as a new wound healing agent and further suggests that MAAs might be a novel biomaterial for wound healing therapies.
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