期刊
MARINE DRUGS
卷 13, 期 5, 页码 2559-2579出版社
MDPI AG
DOI: 10.3390/md13052559
关键词
excavatolide B; carrageenan; lipopolysaccharide; inducible nitric oxide synthase (iNOS); cycloxygenase-2 (COX-2); anti-inflammatory
资金
- Ministry of Science and Technology of Taiwan [MOST 103-2325-B-110-001, MOST 103-2628-B-110-002-MY3]
- Pingtung Christian Hospital, Taiwan
In recent years, several marine-derived compounds have been clinically evaluated. Diterpenes are secondary metabolites from soft coral that exhibit anti-inflammatory, anti-tumor and cytotoxic activities. In the present study, we isolated a natural diterpene product, excavatolide B, from cultured Formosan gorgonian Briareum excavatum and investigated its anti-inflammatory activities. We found that excavatolide B significantly inhibited the mRNA expression of the proinflammatory mediators, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), in lipopolysaccharide (LPS)-challenged murine macrophages (RAW 264.7). We also examined the anti-inflammatory and anti-nociceptive effects of excavatolide B on intraplantar carrageenan-induced inflammatory responses. Excavatolide B was found to significantly attenuate carrageenan-induced nociceptive behaviors, mechanical allodynia, thermal hyperalgesia, weight bearing deficits and paw edema. In addition, excavatolide B inhibited iNOS, as well as the infiltration of immune cells in carrageenan-induced inflammatory paw tissue.
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