期刊
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
卷 60, 期 5, 页码 1401-1413出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBME.2012.2237399
关键词
Electroencephalogram (EEG); epileptic seizure prediction; variational Gaussian mixture model (GMM); zero-crossing intervals
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- University of British Columbia
A novel patient-specific seizure prediction method based on the analysis of positive zero-crossing intervals in scalp electroencephalogram (EEG) is proposed. In a moving-window analysis, the histogram of these intervals for the current EEG epoch is computed, and the values corresponding to specific bins are selected as an observation. Then, the set of observations from the last 5 min is compared with two reference sets of data points (preictal and interictal) through novel measures of similarity and dissimilarity based on a variational Bayesian Gaussian mixture model of the data. A combined index is then computed and compared with a patient-specific threshold, resulting in a cumulative measure which is utilized to form an alarm sequence for each channel. Finally, this channel-based information is used to generate a seizure prediction alarm. The proposed method was evaluated using similar to 561 h of scalp EEG including a total of 86 seizures in 20 patients. A high sensitivity of 88.34% was achieved with a false prediction rate of 0.155 h(-1) and an average prediction time of 22.5 min for the test dataset. The proposed method was also tested against a Poisson-based random predictor.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据