期刊
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
卷 59, 期 4, 页码 1012-1021出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBME.2011.2182195
关键词
Arterial input function (AIF); blind deconvolution; dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI); multichannel; perfusion; single channel
资金
- Helse Vest [170665]
- Research Council of Norway
- Czech Science Foundation [GA102/09/1690]
- European Commission (EC)
- Ministry of Education, Youth and Science (MEYS) Czech Republic [CZ.1.05/2.1.00/01.0017]
Multipass dynamic MRI and pharmacokinetic modeling are used to estimate perfusion parameters of leaky capillaries. Curve fitting and nonblind deconvolution are the established methods to derive the perfusion estimates from the observed arterial input function (AIF) and tissue tracer concentration function. These nonblind methods are sensitive to errors in the AIF, measured in some nearby artery or estimated by multichannel blind deconvolution. Here, a single-channel blind deconvolution algorithm is presented, which only uses a single tissue tracer concentration function to estimate the corresponding AIF and tissue impulse response function. That way, many errors affecting these functions are reduced. The validity of the algorithm is supported by simulations and tests on real data from mouse. The corresponding nonblind and multichannel methods are also presented.
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