期刊
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
卷 58, 期 7, 页码 1891-1899出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBME.2011.2107553
关键词
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资金
- NSF
- NDSEG
- William R. Hewlett Stanford Graduate Fellowship
- Human Frontier Science Program Fellowship
- German Academic Exchange Service
- NIH-NINDS [R01-NS066311]
- Stanford Institute for Neuro-Innovation and Translational Neuroscience (SINTN)
- Stanford Bio-X/NeuroVentures Program
- William M. Keck Foundation
- Snyder Foundation
- Albert Yu and Mary Bechmann Foundation
- Wallace Coulter Foundation
- CIRM
- McKnight Foundation
- Esther A. and Joseph Klingenstein Fund
- NIMH
- NIDA
- NIH [DP1-OD006409]
- DARPA REPAIR [N66001-10-C-2010]
- Burroughs Wellcome Fund
- Christopher and Dana Reeve Foundation
- NIH-NINDS BRP [R01-NS064318]
- SINTN
Neural prosthetic systems aim to help disabled patients by translating neural signals from the brain into control signals for guiding computer cursors, prosthetic arms, and other assistive devices. Intracortical electrode arrays measure action potentials and local field potentials from individual neurons, or small populations of neurons, in the motor cortices and can provide considerable information for controlling prostheses. Despite several compelling proof-of-concept laboratory animal experiments and an initial human clinical trial, at least three key challenges remain which, if left unaddressed, may hamper the translation of these systems into widespread clinical use. We review these challenges: achieving able-bodied levels of performance across tasks and across environments, achieving robustness across multiple decades, and restoring able-bodied quality proprioception and somatosensation. We also describe some emerging opportunities for meeting these challenges. If these challenges can be largely or fully met, intracortically based neural prostheses may achieve true clinical viability and help increasing numbers of disabled patients.
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