期刊
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
卷 57, 期 10, 页码 2609-2612出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBME.2010.2058111
关键词
Follicular lymphoma (FL); k-means; morphology; watershed; whole slides
资金
- National Cancer Institute [R01CA134451]
Follicular lymphoma (FL) is one of the most common types of nonHodgkin lymphoma in the U. S. Diagnosis of FL is based on tissue biopsy that shows characteristic morphologic and immunohistochemical (IHC) findings. Our group's work focuses on the development of computer-aided image-analysis techniques to improve the FL grading. Since centroblast enumeration needs to be performed in malignant follicles, the development of an automated system to accurately identify follicles on digital images of lymphoid tissue is an important step. In this letter, we describe an automated system to identify follicles in IHC-stained tissue sections. A unique feature of the system described here is the use of texture and color information to mimic the process that a human expert might use to identify follicle regions. Comparison of system-generated results with expert-generated ground truth has shown promising results with a mean similarity score of 87.11%.
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