4.6 Article

A Combined Fluorescence and Microcomputed Tomography System for Small Animal Imaging

期刊

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
卷 57, 期 12, 页码 2876-2883

出版社

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBME.2010.2073468

关键词

Dual-modal imaging; fluorescence molecular tomography (FMT); image reconstruction; micro-cone-beam computed tomography (micro-CBCT)

资金

  1. National Natural Science Foundation of China [60831003, 81071191, 30930092, 30872633]
  2. Tsinghua-Yue-Yuen Medical Science Foundation
  3. National Basic Research Program of China (973) [2006CB705700, 2011CB707701]
  4. National High-Tech Research and Development Program of China (863) [2006AA020803]

向作者/读者索取更多资源

Fluorescence molecular tomography (FMT) plays an important role in studying physiological and pathological processes of small animals in vivo at molecular level. However, this technique suffers from relatively low spatial resolution. To complement the problem, there has been a strong demand for providing functional and morphological analysis at the same time. In this paper, we proposed a hybrid full-angle free-space FMT and X-ray microcone-beam computed tomography (CT) (micro-CBCT) prototype system, providing both functional and anatomical images. During the whole acquisition, the two subsystems acquire projection images (fluorescence and CT) synchronously to keep consistent body position without moving the animals. The acquired datasets are intrinsically coregistered in the corresponding coordinate and identified geometry. Tomographic fluorescence and CT images are reconstructed using normalized Born-based spatial regularization and Feldkamp-Davis-Kress methods, respectively. The experimental results of both phantom and in vivo mouse preliminarily validate the accuracy and performance of the integrated system.

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