期刊
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
卷 56, 期 6, 页码 1765-1768出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBME.2008.2011647
关键词
Cerebrospinal fluid (CSF) hydrodynamics; cine MR; pulse wave velocity (PWV); spinal cord pathology assessment; subarachnoid space (SAS)
资金
- American Syringomyelia Alliance
Noninvasive measurement of the speed with which the cerebrospinal fluid (CSF) velocity wave travels through the spinal canal is of interest as a potential indicator of CSF system pressure and compliance, both of which may play a role in the development of craniospinal diseases. However, measurement of CSF velocity wave speed (VWS) has eluded researchers primarily due to either a lack of access to CSF velocity measurements or poor temporal resolution. Here, we present a CSF VWS measurement methodology using a novel MR sequence that acquires unsteady velocity measurements during the cardiac cycle with a time interval <10 ins. Axial CSF velocity measurements were obtained in the sagittal plane of the cervical spinal region on three subjects referred for an MRI scan without craniospinal disorders. CSF VWS was estimated by using the time shift identified by the maximum velocity and maximum temporal velocity gradient during the cardiac cycle. Based on the maximum velocity gradient, the mean VWS in the three cases was calculated to be 4.6 m/s (standard deviation 1.7 m/s, p < 0.005) during systolic acceleration. VWS computed using maximum velocity alone was not statistically significant for any of the three cases. The measurements of VWS are close in magnitude to previously published values. The methodology represents a new technique that can be used to measure VWS in the spinal canal non-invasively. Further research is required to both validate the measurements and determine clinical significance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据