期刊
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
卷 55, 期 3, 页码 857-865出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBME.2008.915665
关键词
control set-point trajectory; glucose control; insulin sensitivity; PID controller; switching; type 1 diabetes
资金
- NIDDK NIH HHS [R21-DK069833, R21-DK069833-02] Funding Source: Medline
In order for an artificial pancreas to become a reality for ambulatory use, a practical closed-loop control strategy must be developed and validated. In this paper, an improved PID control strategy for blood glucose control is proposed and critically evaluated in silico using a physiologic model of Hovorka et al. [1]. The key features of the proposed control strategy are: 1) a switching strategy for initiating PID control after a meal and insulin bolus; 2) a novel time-varying setpoint trajectory; 3) noise and derivative filters to reduce sensitivity to sensor noise; and 4) a practical controller tuning strategy. Simulation results demonstrate that proposed control strategy compares favorably to alternatives for realistic conditions that include meal challenges, incorrect carbohydrate meal estimates, changes in insulin sensitivity, and measurement noise.
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