期刊
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
卷 55, 期 1, 页码 257-266出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBME.2007.900540
关键词
bioelectric potentials; biomagnetics; biomembranes; electric fields; energy measurement; heating; insulated gate bipolar transistors; magnetic fields; neuromuscular stimulation; pulse generation; pulse power systems; pulse shaping circuits; pulse width (PW); transcranial magnetic stimulation (TMS)
资金
- NIBIB NIH HHS [R21 EB006855] Funding Source: Medline
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R21EB006855] Funding Source: NIH RePORTER
A novel transcranial magnetic stimulation (TMS) device with controllable pulse width (PW) and near-rectangular pulse shape (cTMS) is described. The cTMS device uses an insulated gate bipolar transistor (IGBT)) with appropriate snubbers to switch coil currents up to 6 kA, enabling PW control from 5 mu s to over 100 mu s. The near-rectangular induced electric field pulses use 2%-34% less energy and generate 67% -72% less coil heating compared, to matched conventional cosine pulses. CTMS is used to stimulate rhesus monkey motor cortex in vivo with PWs of 20 to 100 mu s; demonstrating the expected decrease of threshold pulse amplitude with increasing PW. The technological solutions used in the cTMS prototype can expand functionality, and reduce power consumption and coil heating in TMS, enhancing its research and therapeutic applications.
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