期刊
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
卷 8, 期 1, 页码 87-97出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBCAS.2014.2303160
关键词
Duplication-divergence model; evolution; important; node; protein-protein interaction network; structurally dominant protein
资金
- National Natural Science and Technology Major Project of China [2014ZX10004-001-014]
- 973 Project [2014CB845302]
- National Natural Science Foundation of China [61025017, 61304151, 11105040]
- Australia ARC Discovery Grant [DP130104765]
- Science Foundation of Henan University [2012YBZR007, 2013YBRW005]
It is well known that protein-protein interaction (PPI) networks are typical evolving complex networks. Identification of important nodes has been an emerging popular topic in complex networks. Many indexes have been proposed to measure the importance of nodes in complex networks, such as degree, closeness, betweenness, k-shell, clustering coefficient, semi-local centrality, eigenvector centrality. Based on multivariate statistical analysis, through integrating the above indexes and further considering the appearances of nodes in network motifs, this paper aims at developing a new measure to characterize the structurally dominant proteins (SDP) in PPI networks. Moreover, we will further investigate the evolution of the defined dominant nodes in temporal evolving real-world and artificial PPI networks. Our results indicate that the constructed artificial networks have some similar statistical properties as those of the real-world evolving networks. In this case, the artificial PPI networks can be used to further investigate the above evolution characteristics of the real-world evolving networks. Simulation results reveal that SDP in the yeast PPI networks are evolutionary conserved, however, the undominant nodes evolve rapidly. Furthermore, PPI networks are very robust against random mutations, while fragile yet with certain robustness to targeted mutations on SDP. Our investigations shed some light on the future applications of the evolving characteristics of bio-molecular networks, such as reengineering of particular networks for technological, synthetic or pharmacological purposes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据