期刊
MAGNETIC RESONANCE IMAGING CLINICS OF NORTH AMERICA
卷 23, 期 2, 页码 217-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.mric.2015.01.003
关键词
MR imaging; Lung imaging; Hyperpolarized gas; Pulmonary ventilation; Pulmonary gas exchange; Xenon (Xe-129)
资金
- NIH/NHLBI [R01 HL105643]
- Duke Center for In Vivo Microscopy, an NIH/NIBIB national Biomedical Technology Resource Center [P41 EB015897]
Functional imaging offers information more sensitive to changes in lung structure and function. Hyperpolarized helium (He-3) and xenon (Xe-129) MR imaging of the lungs provides sensitive contrast mechanisms to probe changes in pulmonary ventilation, microstructure, and gas exchange. Gas imaging has shifted to the use of Xe-129. Xenon is well-tolerated. Xe-129 is soluble in pulmonary tissue, which allows exploring specific lung function characteristics involved in gas exchange and alveolar oxygenation. Hyperpolarized gases and Xe-129 in particular stand to be an excellent probe of pulmonary structure and function, and provide sensitive and noninvasive biomarkers for pulmonary diseases.
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