期刊
MACROMOLECULAR RAPID COMMUNICATIONS
卷 37, 期 5, 页码 439-445出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201500590
关键词
cell sorting; circulating tumor cells; thermoresponsive nanogels; transferrin
资金
- CONICET
- SECyT-UNC
- FONCYT
- collaborative research center [SFB1112]
- NanoMatFutur award [13N12561]
- BMBF-Mincyt
- Conicet-DFG
- Dahlem Research Center
- Freie Universitat Berlin within the Excellence Initiative of the German Research Foundation
- DAAD
A rational design of magnetic capturing nanodevices, based on a specific interaction with circulating tumor cells (CTCs), can advance the capturing efficiency and initiate the development of modern smart nanoformulations for rapid isolation and detection of these CTCs from the bloodstream. Therefore, the development and evaluation of magnetic nanogels (MNGs) based on magnetic nanoparticles and linear thermoresponsive polyglycerol for the capturing of CTCs with overexpressed transferrin (Tf+) receptors has been presented in this study. The MNGs are synthesized using a strain-promoted click approach which has allowed the in situ surface decoration with Tf-polyethylene glycol (PEG) ligands of three different PEG chain lengths as targeting ligands. An optimal value of around 30% of cells captures is achieved with a linker of eight ethylene glycol units. This study shows the potential of MNGs for the capture of CTCs and the necessity of precise control over the linkage of the targeting moiety to the capturing device.
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