期刊
MACROMOLECULAR MATERIALS AND ENGINEERING
卷 300, 期 6, 页码 596-610出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mame.201400369
关键词
anti-inflammatory drugs; drug loading; impregnation; mechanical properties; polymer sutures; supercritical carbon dioxide
资金
- Conseil Regional Aquitaine through international doctoral school program IDS-FunMat - European Community (ERASMUS MUNDUS Doctoral program)
This paper aims at exploring the scCO(2) impregnation of three commonly implanted polymer sutures made of poly-l-lactide (PLLA), poly(ethylene terephthalate) (PET) and polypropylene (PP) with two anti-inflammatory drugs namely ketoprofen and aspirin. For all the investigated polymer/drug systems, the drug loading increases with temperature and pressure. It appears that two main criteria must be fulfilled by the polymer to achieve high drug loading: (i) a good affinity between the polymer and the drug and (ii) a high chain mobility to favor the diffusion of the drug into the matrix. As the investigated PLLA fulfills these two requirements, drug loading up to 32.5% with ketoprofen and 8.1% with aspirin has been achieved.
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